Amenstic disorder

Subacute organic psychiatric syndrome characterized by prominent impairment in ability to learn new information & unable to recall learned information, without absence of generalized intellectual impairment.

Lesions:

Posterior hypothalamus

Bilateral hippocampal lesions

Degenerative changes of mammillary bodies

Haemorrhagic lesions around 3^rd & 4^th ventricles

Etiology: Dietary deficiency of  Vit—B1

                      Alcohol abuse

                      gastric carcinoma

                       Persistent puerperal sepsis, vomiting, typhoid fever

Other causes---> vascular lesion in CNS

                            CO poisoning

                             Head injury

                              Surgery in  CNS

Clinical features:

1.      Korsakov’s syndrome → a Chronic syndrome . Following S/S are—

       Memory deficit( recent), Confabulation ( fabrication of  memory), irritability, peripheral neuropathy.

2.      Wernicke’s encephalopathy ---> acute condition. Following S/S are---

         Impaired consciousness, memory deficit( recent), disorientation of  time, ophthalmoplegia and  nystegmus

                                                        

Treatment: Stop alcohol in case of  alcoholic patients.

                           Injection B1 daily

Vitamin B complex orally

Diet rich in Vit-B complex.

PSORIASIS: